![]() There has been no comprehensive analysis of the age-specific efficacy of G-CSF to prevent febrile neutropenia (FN). Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Matsuda, K., Jo, T., Miyauchi, M., Toyama, K., Nakazaki, K., Matsui, H., Fushimi, K., Yasunaga, H., Kurokawa, M. Difference of preventing effects of G-CSF according to age in patients with malignant lymphoma: A nation-wide analysis in Japan.This platform should facilitate the administration of human neutrophils for a broad spectrum of physiological and pathological conditions. This system potentially provides a straight-forward solution for patients with neutrophil deficiency-an off-the-shelf neutrophil transfusion. In addition, we found that these human neutrophil-like cells can recruit murine immune cells. ![]() Using five different mouse models, we systematically demonstrated that these neutrophil-like cells migrate to sites of inflammation and infection and increase survival against bacterial infection. Here, we show that engineered neutrophil-primed progenitors derived from human induced pluripotent stem cells (iPSCs) can produce functional neutrophil-like cells at a clinically applicable scale that can act rapidly in vivo against lethal bacterial infections. Neutrophils play an essential role in innate immune responses to bacterial and fungal infections and loss of neutrophil function can increase the risk of acquiring lethal infections in clinical settings.
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